Asymmetric Synthesis of cis-5-(Aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3H)- one

초록

The asymmetric synthesis of (3R,5S )-5-(aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3 H )-one, as the most potent selective inactivator of monoamine B, was successfully achieved by applying a newly developed synthetic method toward the key -aminomethyl--lactone via intramolecular aziridine ring opening in 63% overall yield from a commercial starting material.

키워드