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Highly Improved Copper-Mediated Michael Addition of Ethyl Bromodifluoroacetate in the Presence of Protic Additive
- Kim, Bong Chan;
- Park, Aeri;
- An, Ji Eun;
- Lee, Won Koo;
- Lee, Hee Bong;
- 외 1명
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13Citations
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14초록
Copper-mediated Michael addition of ethyl bromodifluoroacetate to Michael acceptors is accompanied by the formation of a substantial amount of byproducts. Elucidation of their structure hinted the cause of their formation, from which we discovered a highly improved and robust protocol by treatment with protic additives such as H2O and AcOH. This modification led to significant increase of yield with concomitant decreased use of reagent.
키워드
copper; coupling; fluorine; Michael addition; protonation; CONJUGATE ADDITION; FLUORINE
- 제목
- Highly Improved Copper-Mediated Michael Addition of Ethyl Bromodifluoroacetate in the Presence of Protic Additive
- 저자
- Kim, Bong Chan; Park, Aeri; An, Ji Eun; Lee, Won Koo; Lee, Hee Bong; Shin, Hyunik
- 발행일
- 2012-10
- 유형
- Article
- 저널명
- Synthesis
- 권
- 44
- 호
- 20
- 페이지
- 3165 ~ 3170