Synthesis of constrained ceramide analogs and their potent antileukemic activities

Ha, HJ; Hong, MC; Ko, SW; Kim, YW; Lee, WK; Park, J

doi:10.1016/j.bmcl.2005.12.091

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Synthesis of constrained ceramide analogs and their potent antileukemic activities

Ha, HJ;
Hong, MC;
Ko, SW;
Kim, YW;
Lee, WK;
외 1명

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24

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25

초록

Constrained ceramide analogs were designed and synthesized by binding terminal alcohol and amine of ceramide with additional carbonyl functional group as 3-acetyl (3), 3-propionyl (4), 3-benzoyl (5), and 3-hexadecanoyl-4-(1-hydroxyhexadec-2-enyl)-oxazolidin-2-ones (6). Compounds 4 and 5 showed potent antileukemic activities against human leukemia HL-60 cells with good correlation between cell death and DNA fragmentation. (C) 2006 Elsevier Ltd. All rights reserved.

키워드

constrained; ceramide; analogs; antileukemic; apoptosis; MEDIATED CYTOTOXICITY; SPHINGOLIPID ANALOGS; SPHINGOSINE; INDUCTION; APOPTOSIS; METABOLISM; CHEMISTRY; CELLS; BOND

제목: Synthesis of constrained ceramide analogs and their potent antileukemic activities

저자: Ha, HJ; Hong, MC; Ko, SW; Kim, YW; Lee, WK; Park, J

DOI: 10.1016/j.bmcl.2005.12.091

발행일: 2006-04-01

유형: Article

저널명: Bioorganic and Medicinal Chemistry Letters

권: 16

호: 7

페이지: 1880 ~ 1883