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Synthesis of substituted-(l)-tryptophanols from an enantiomerically pure aziridine-2-methanol
- Pyun, DK;
- Lee, CH;
- Ha, HJ;
- Park, CS;
- Chang, JW;
- ... Lee, WK
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21초록
[GRAPHICS] Enantiomerically pure (l)-tryptophanol (5) was synthesized from 4(R)-iodomethyl-2-oxazolidinone (2) and indolylmagnesium bromide in three steps (52% overall yield). Using this procedure, we also prepared various tryptophanols with substituent(s) on the indole ring. Furthermore, optically active 4(R)-iodomethyl-2-oxazolidinone was readily prepared from an enantiomerically pure aziridine-2(S)-methanol in high yield.
키워드
DNA TOPOISOMERASE-II; ENANTIOSPECIFIC SYNTHESIS; INDOLYLMAGNESIUM BROMIDE; EFFICIENT SYNTHESIS; ANALOGS; DERIVATIVES; CLEAVAGE
- 제목
- Synthesis of substituted-(l)-tryptophanols from an enantiomerically pure aziridine-2-methanol
- 저자
- Pyun, DK; Lee, CH; Ha, HJ; Park, CS; Chang, JW; Lee, WK
- 발행일
- 2001-12-27
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 3
- 호
- 26
- 페이지
- 4197 ~ 4199