Enantioselective synthesis of the C1-C28 portion of the cytotoxic natural product, amphidinolide B1

Lee, DH; Lee, SW

doi:10.1016/S0040-4039(97)10103-4

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Enantioselective synthesis of the C1-C28 portion of the cytotoxic natural product, amphidinolide B1

Lee, DH;
Lee, SW

Citations

WEB OF SCIENCE

34

Citations

SCOPUS

34

초록

The C1-C28 portion of the cytotoxic natural product, amphidinolide B1 (1a) was synthesized enantioselectively using as key steps Evans chiral oxazolidinone chemistry, Sharpless asymmetric epoxidation, and the orthoester Claisen rearrangement The overall yield is 3.6% in 13 step sequence starting from propionyl oxazolidinone 2. (C) 1997 Elsevier Science Ltd.

키워드

ABSOLUTE STEREOCHEMISTRY; DINOFLAGELLATE; MACROLIDE

제목: Enantioselective synthesis of the C1-C28 portion of the cytotoxic natural product, amphidinolide B1

저자: Lee, DH; Lee, SW

DOI: 10.1016/S0040-4039(97)10103-4

발행일: 1997-11-10

유형: Article

저널명: Tetrahedron Letters

권: 38

호: 45

페이지: 7909 ~ 7910