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Organocatalytic Atroposelective Synthesis of Isoquinolines via Dynamic Kinetic Resolution
- Kim, Ahreum;
- Moon, Junsoo;
- Lee, Chanhee;
- Song, Jayoung;
- Kim, Jongchan;
- 외 1명
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12초록
Herein, a highly enantioselective Pictet-Spengler react on for the synthesis of axially chiral tetrahydroisoquinolines via dynamic kinetic resolution is described. Chiral phosphoric acids catalyze cyclization to yield single regioisomeric isoquinolines with excellent enantioselectivities around the C-C bond up to 99% ee. The current protocol is effective for a wide range of substrates, and the observed enantiodivergence depends on the substituents on the catalysts.
키워드
ASYMMETRIC TRANSFER HYDROGENATION; PICTET-SPENGLER REACTIONS; BIARYL COMPOUNDS; ALKALOIDS; STRATEGY
- 제목
- Organocatalytic Atroposelective Synthesis of Isoquinolines via Dynamic Kinetic Resolution
- 저자
- Kim, Ahreum; Moon, Junsoo; Lee, Chanhee; Song, Jayoung; Kim, Jongchan; Kwon, Yongseok
- 발행일
- 2022-02-04
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 24
- 호
- 4
- 페이지
- 1077 ~ 1082