A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Yamauchi, Toshimasa; Hara, Kazuo; Maeda, Shiro; Yasuda, Kazuki; Takahashi, Atsushi; Horikoshi, Momoko; Nakamura, Masahiro; Fujita, Hayato; Grarup, Niels; Cauchi, Stephane; Ng, Daniel P. K.; Ma, Ronald C. W.; Tsunoda, Tatsuhiko; Kubo, Michiaki; Watada, Hirotaka; Maegawa, Hiroshi; Okada-Iwabu, Miki; Iwabu, Masato; Shojima, Nobuhiro; Shin, Hyoung Doo; Andersen, Gitte; Witte, Daniel R.; Jorgensen, Torben; Lauritzen, Torsten; Sandbaek, Annelli; Hansen, Torben; Ohshige, Toshihiko; Omori, Shintaro; Saito, Ikuo; Kaku, Kohei; Hirose, Hiroshi; So, Wing-Yee; Beury, Delphine; Chan, Juliana C. N.; Park, Kyong Soo; Tai, E. Shyong; Ito, Chikako; Tanaka, Yasushi; Kashiwagi, Atsunori; Kawamori, Ryuzo; Kasuga, Masato; Froguel, Philippe; Pedersen, Oluf; Kamatani, Naoyuki; Nakamura, Yusuke; Kadowaki, Takashi

doi:10.1038/ng.660

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A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Yamauchi, Toshimasa;
Hara, Kazuo;
Maeda, Shiro;
Yasuda, Kazuki;
Takahashi, Atsushi;
... Shin, Hyoung Doo;
외 40명

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초록

We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 x 10(-9); rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 x 10(-9)). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 x 10(-14), whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.

키워드

UBIQUITIN-PROTEASOME SYSTEM; FASTING PLASMA-GLUCOSE; INSULIN-RESISTANCE; GENETIC-VARIATION; RISK LOCI; VARIANT; REPLICATION; STRATIFICATION; HOMEOSTASIS; MTNR1B

제목: A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

저자: Yamauchi, Toshimasa; Hara, Kazuo; Maeda, Shiro; Yasuda, Kazuki; Takahashi, Atsushi; Horikoshi, Momoko; Nakamura, Masahiro; Fujita, Hayato; Grarup, Niels; Cauchi, Stephane; Ng, Daniel P. K.; Ma, Ronald C. W.; Tsunoda, Tatsuhiko; Kubo, Michiaki; Watada, Hirotaka; Maegawa, Hiroshi; Okada-Iwabu, Miki; Iwabu, Masato; Shojima, Nobuhiro; Shin, Hyoung Doo; Andersen, Gitte; Witte, Daniel R.; Jorgensen, Torben; Lauritzen, Torsten; Sandbaek, Annelli; Hansen, Torben; Ohshige, Toshihiko; Omori, Shintaro; Saito, Ikuo; Kaku, Kohei; Hirose, Hiroshi; So, Wing-Yee; Beury, Delphine; Chan, Juliana C. N.; Park, Kyong Soo; Tai, E. Shyong; Ito, Chikako; Tanaka, Yasushi; Kashiwagi, Atsunori; Kawamori, Ryuzo; Kasuga, Masato; Froguel, Philippe; Pedersen, Oluf; Kamatani, Naoyuki; Nakamura, Yusuke; Kadowaki, Takashi

DOI: 10.1038/ng.660

발행일: 2010-10

유형: Article

저널명: Nature Genetics

권: 42

호: 10

페이지: 864 ~ +

언어: ENG

출판사: Nature Publishing Group

발행국가: 미국

ISSN: E 1546-1718
P 1061-4036