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Synthesis of Substituted Imidazolidin-2-ones as Aminoacyl-tRNA Synthase Inhibitors
- Eum, Heesung;
- Lee, Yuno;
- Kim, Songmi;
- Baek, Ayoung;
- Son, Minky;
- ... Lee, Won Koo;
- 외 5명
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5초록
Substituted imidazolidin-2-ones deduced as potential inhibitors of IleRS by docking simulations were synthesized from an aziridine-2-carboxaldehyde. Reductive amination of an aziridine-2-carboxaldehyde with dipeptides for the substituents at N1 and followed by aziridine-ring expansion with triphosgene afforded 4-chloromethylimidazolidin-2-ones whose chloride were further manipulated towards phenylurea, pyrimidin-2-yl-urea or benzenesulfonamide at C4.
키워드
Aminoacyl-tRNA synthase inhibitors; Imidazolidin-2-ones; PSEUDOMONIC ACID; STAPHYLOCOCCUS-AUREUS; EFFICIENT SYNTHESIS; ESCHERICHIA-COLI; SYNTHETASE; MUPIROCIN; RESISTANCE
- 제목
- Synthesis of Substituted Imidazolidin-2-ones as Aminoacyl-tRNA Synthase Inhibitors
- 저자
- Eum, Heesung; Lee, Yuno; Kim, Songmi; Baek, Ayoung; Son, Minky; Lee, Keun Woo; Ko, Seung Whan; Kim, Sunghoon; Yun, Sae Young; Lee, Won Koo; Ha, Hyun-Joon
- 발행일
- 2010-03-20
- 유형
- Article
- 권
- 31
- 호
- 3
- 페이지
- 611 ~ 614