Computational kinetic study of chemotactic cell migration

초록

The interaction between the cell and the substrate is the most prominent feature of the crawling cell. Here, a three-dimensional dynamic chemotaxis model for a crawling cell is proposed based on the diffuse interface description. From the computational analysis, the interfacial effect on the chemotactic migration is systematically analyzed with respect to an energetic and kinetic view. Quantitative information about the interfacial effect on the chemotactic migration is provided with a suggested correlation coefficient that defines the relation between the surface tension and the adhesion strength. Moreover, the analyzed kinetic effect elucidates the chemotactic migration of cells on morphologically patterned substrates. The developed approach provides considerably reliable information for the effective experimental control of crawling cells with the condition of a substrate. (C) 2013 AIP Publishing LLC.

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