Experimental study of ultrasound-triggered vaporization of microdroplets on a wall

초록

Ultrasound-triggered vaporization of dodecafluoropentane (DDFP) droplets has great potential for local drug delivery, especially when in contact with target tissues or areas to be treated. The dynamic motion of phase-changing (PC) droplets on a wall was experimentally investigated using high speed imaging and compared to non-phase-changing (NPC) bubble motion. Micro-sized PC droplets and NPC bubbles were exposed to ultrasound pulses of 0.6-3 MPa at 5 MHz as conditions that satisfy the FDA recommended mechanical index. The volume expansion due to phase change was found to promote the detachment of PC droplets from the wall. The effects of droplet or bubble size and ultrasound amplitude on the dynamic motion of PC droplets and NPC bubbles were quantified.

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