한국인 정신분열병　환자의 안구추적운동 이상과 COMT 유전자의 Val108/158Met 다형성의 연합 연구

초록

Objectives : We investigated the association of Val108/158Met polymorphism on catechol-O-methyl transferase (COMT) gene with smooth pursuit eye movement (SPEM) abnormality in Korean schizophrenia patients. Methods : We measured SPEM function in 217 Korean schizophrenia patients　(male 116, female 101) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. Then we analyzed Val108/158Met polymorphism on COMT gene. We compared the differences of genotype and allele distributions of the polymorphism on COMT gene between the two groups. Results : The natural logarithm value of signal/noise ratio (Ln S/N ratio)　of the good SPEM function group was 4.39 ± 0.33 (mean ± s.d.) and that of poor SPEM function group was 3.17 ± 0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the Val108/158Met polymorphism on COMT gene between the two schizophrenic groups. Conclusions : The results suggest that Val108/158Met polymorphism on COMT gene is not related to SPEM function abnormality in schizophrenia.

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