Dihydroxylation of 2-vinylaziridine:: efficient synthesis of D-ribo-phytosphingosine

  • Yoon, Hyo Jae
  • Kim, Yong-Woo
  • Lee, Baeck Kyoung
  • Lee, Won Koo
  • Kim, Yongeun
  • 외 1명
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초록

An efficient and highly stereoselective synthesis of D-ribo-(2S, 3S, 4R)-phytosphingosine was accomplished in 62% overall yield starting from commercially available (2S)-hydroxymethylaziridine via osmium-catalyzed asymmetric dihydroxylation as a key step.

키워드

SACCHAROMYCES-CEREVISIAESTEREOSPECIFIC SYNTHESISFACILE SYNTHESISSPHINGOID BASESSPHINGOLIPIDSCERAMIDESCHEMISTRYTRANSPORTANALOGSMUCOSA
제목
Dihydroxylation of 2-vinylaziridine:: efficient synthesis of D-ribo-phytosphingosine
저자
Yoon, Hyo JaeKim, Yong-WooLee, Baeck KyoungLee, Won KooKim, YongeunHa, Hyun-Joon
DOI
10.1039/b612740a
발행일
2007
유형
Article
저널명
Chemical Communications
1
페이지
79 ~ 81