Design and application of hybrid terahertz metasurface for selective target detection in complex biochemical systems

초록

Terahertz (THz) spectroscopy offers unique advantages for biochemical analysis by probing intermolecular interactions and dynamic environmental changes. However, its application is greatly hindered by spectral limitations such as water absorption, and the severe dimensional mismatch between the THz wave and biological components. To address these challenges, this study proposes a hybrid metasurface platform designed for highly selective and sensitive sensing in complex biochemical systems. This platform integrates a periodically aligned gold nanoslot array on a surface-functionalized substrate to implement strong local field confinement along with the surface functionalization for selective target capture. The negatively-patterned nanoslot structure generates pseudo-plasmonic resonance mode, creating optical hotspots, while a thermally oxidized SiO2 substrate facilitates surface functionalization and mitigates impedance mismatch to broaden the active sensing area along the near-field region. This synergistic design maximizes light-matter interaction by positioning the target analyte directly within the localized electric field. Featuring tunability, scalability, and cost-effectiveness, the proposed platform allows effective sensing performance across micro-, multi-, and macro-scale biochemical systems. By successfully defining the hybrid THz metasurface sensing platform with target selectivity, the tailored strategy enables the precise and dynamic analysis of diverse aqueous biochemical systems, overcoming conventional spectral limitations. © COPYRIGHT SPIE.

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