Defective GATA-3 expression in Th2 LCR-deficient mice

Hwang, Soo Seok; Kim, Kiwan; Lee, Gap Ryol

doi:10.1016/j.bbrc.2011.06.080

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Defective GATA-3 expression in Th2 LCR-deficient mice

Hwang, Soo Seok;
Kim, Kiwan;
Lee, Gap Ryol

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8

초록

Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6. Histone 3 lysine 4 (H3-K4) was hypomethylated in the gata3 locus in these cells. GATA-3 and STAT6 bound several regulatory regions in the gata3 locus and transactivated the expression of the gata3 gene. These results suggest that Th2 differentiation program stimulates feed-forward regulation of gata3 gene expression. (C) 2011 Elsevier Inc. All rights reserved.

키워드

GATA-3; Th2 LCR; STAT6; Th2 differentiation; Chromatin remodeling; LOCUS-CONTROL REGION; HELPER TYPE-2 CELLS; CYTOKINE LOCUS; T-CELLS; TRANSCRIPTION FACTORS; GENE-EXPRESSION; DIFFERENTIATION; NOTCH; MAINTENANCE; COMMITMENT

제목: Defective GATA-3 expression in Th2 LCR-deficient mice

저자: Hwang, Soo Seok; Kim, Kiwan; Lee, Gap Ryol

DOI: 10.1016/j.bbrc.2011.06.080

발행일: 2011-07-15

유형: Article

저널명: Biochemical and Biophysical Research Communications

권: 410

호: 4

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