상세 보기
Defective GATA-3 expression in Th2 LCR-deficient mice
- Hwang, Soo Seok;
- Kim, Kiwan;
- Lee, Gap Ryol
Citations
WEB OF SCIENCE
7Citations
SCOPUS
8초록
Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6. Histone 3 lysine 4 (H3-K4) was hypomethylated in the gata3 locus in these cells. GATA-3 and STAT6 bound several regulatory regions in the gata3 locus and transactivated the expression of the gata3 gene. These results suggest that Th2 differentiation program stimulates feed-forward regulation of gata3 gene expression. (C) 2011 Elsevier Inc. All rights reserved.
키워드
GATA-3; Th2 LCR; STAT6; Th2 differentiation; Chromatin remodeling; LOCUS-CONTROL REGION; HELPER TYPE-2 CELLS; CYTOKINE LOCUS; T-CELLS; TRANSCRIPTION FACTORS; GENE-EXPRESSION; DIFFERENTIATION; NOTCH; MAINTENANCE; COMMITMENT
- 제목
- Defective GATA-3 expression in Th2 LCR-deficient mice
- 저자
- Hwang, Soo Seok; Kim, Kiwan; Lee, Gap Ryol
- 발행일
- 2011-07-15
- 유형
- Article
- 권
- 410
- 호
- 4
- 페이지
- 866 ~ 871
- 언어
- ENG
- 출판사
- Academic Press
- 발행국가
- 미국
- 분량
- 6 페이지
- ISSN
- E 1090-2104
P 0006-291X