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N-Methylative aziridine ring opening and asymmetric synthesis of MeBmt
- Kim, Yongeun;
- Yoon, Doo-Ha;
- Ha, Hyun-Joon;
- Kang, Kyung Yeon;
- Lee, Won Koo
Citations
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Asymmetric synthesis of MeBmt, an unusual amino acid constituent of cyclosporine A, was achieved from aziridine-(2R)-carboxaldehyde through highly stereoselective addition of (E)-crotylboronate and the subsequent N-methylative aziridine ring opening as key steps. (C) 2011 Elsevier Ltd. All rights reserved.
키워드
MeBmt; Asymmetric synthesis; Aziridine; Ring opening; Crotylation; UNUSUAL AMINO-ACID; STEREOSELECTIVE-SYNTHESIS; FORMAL SYNTHESIS; CHIRAL GLYCINE; CYCLOSPORINE; ALDEHYDES; KETONES
- 제목
- N-Methylative aziridine ring opening and asymmetric synthesis of MeBmt
- 저자
- Kim, Yongeun; Yoon, Doo-Ha; Ha, Hyun-Joon; Kang, Kyung Yeon; Lee, Won Koo
- 발행일
- 2011-11-09
- 유형
- Article
- 권
- 52
- 호
- 45
- 페이지
- 5918 ~ 5920