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Solution-phase parallel synthesis of new 2H-pyrimido-[4,5-e][1,2,4]triazin-3-ylidenecyanamides
- Lee, IY;
- Kim, SY;
- Lee, JY;
- Yu, CM;
- Lee, DH;
- 외 1명
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38초록
A practical synthesis of 2H-pyrimido[4,5-e][1,2,4]triazin-3-ylidenecyanamides has been developed. The key step is the coupling reaction of an aryldiazonium salt with 1-cyano-3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylamino)-2-methylisothiourea followed by intramolecular cyclization. A library of 2H-pyrimido[4,5-e][1,2,4]triazin-3-ylidenecyanamides was prepared in two steps from 6-aminouracils using this method. (C) 2004 Elsevier Ltd. All rights reserved.
키워드
2H-pyrimido[4,5-e][1,2,4]triazin-3-ylidenecyanamides; pyrimidotriazine; solution-phase parallel synthesis; INTRAMOLECULAR CYCLOADDITION; ANTIBIOTICS FERVENULIN; DERIVATIVES; 2-METHYLFERVENULONE; INHIBITORS; CYANOGUANIDINES; 7-AZAPTERIDINE; HETEROCYCLES; PURINES; POTENT
- 제목
- Solution-phase parallel synthesis of new 2H-pyrimido-[4,5-e][1,2,4]triazin-3-ylidenecyanamides
- 저자
- Lee, IY; Kim, SY; Lee, JY; Yu, CM; Lee, DH; Gong, YD
- 발행일
- 2004-12-13
- 유형
- Article
- 권
- 45
- 호
- 51
- 페이지
- 9319 ~ 9322