A formal synthesis of (-)-swainsonine from a chiral aziridine

Choi, Hwan Geun; Kwon, Ji Hye; Kim, Jong Chan; Lee, Won Koo; Eum, Heesung; Ha, Hyun-Joon

doi:10.1016/j.tetlet.2010.04.069

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A formal synthesis of (-)-swainsonine from a chiral aziridine

Choi, Hwan Geun;
Kwon, Ji Hye;
Kim, Jong Chan;
Lee, Won Koo;
Eum, Heesung;
외 1명

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WEB OF SCIENCE

29

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SCOPUS

29

초록

A formal synthesis of enantiomerically pure (-)-swainsonine was successfully achieved using intramolecular cyclization of the amino alcohol 4 which was derived from a readily available 1-(R)-alpha-methylbenzylaziridine-2-carboxylic acid (-)-menthol ester 6. (C) 2010 Elsevier Ltd. All rights reserved.

키워드

ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; DECARBONYLATION; SWAINSONINE; INHIBITORS; ALCOHOLS; ANALOGS

제목: A formal synthesis of (-)-swainsonine from a chiral aziridine

저자: Choi, Hwan Geun; Kwon, Ji Hye; Kim, Jong Chan; Lee, Won Koo; Eum, Heesung; Ha, Hyun-Joon

DOI: 10.1016/j.tetlet.2010.04.069

발행일: 2010-06-23

유형: Article

저널명: Tetrahedron Letters

권: 51

호: 25

페이지: 3284 ~ 3285