Activation Strategies for Alkyl Precursors in Achieving C(sp<SUP>3</SUP>)-C(sp<SUP>3</SUP>) Cross-Coupling via Metallaphotoredox Catalysis

초록

C(sp3)-C(sp3) bond formation is gaining more prominence, especially with a growing emphasis on building three-dimensional chemical space in bioactive molecules, fine chemicals, and agrichemicals. Metallaphotoredox catalysis has emerged as an effective strategy for designing processes using diverse C(sp(3)) precursors well suited for 1e- radical chemistry. This review summarizes the latest advancement in metallaphotoredox catalysis, addressing the long-standing challenges in C(sp(3))-C(sp(3)) cross-coupling, with a focus on the classification of reactions based on the distinct modes of activation of C(sp(3)) precursor upon entering the catalytic cycle.

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