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Genetic incorporation of L-dihydroxyphenylalanine (DOPA) biosynthesized by a tyrosine phenol-lyase and its applications
- Kim, Sang Kil;
- Lee, Hyun Soo
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59초록
l-Dihydroxyphenylalanine (DOPA) was biosynthesized by a tyrosine-phenol lyase from catechol, pyruvate, and ammonia in Escherichia coli, and the biosynthesized amino acid was directly incorporated into proteins. Three biochemical experiments with mutant proteins containing DOPA confirmed the genetic incorporation of biosynthesized DOPA, and revealed its potential for various biochemical applications. © The Royal Society of Chemistry 2018.
키워드
UNNATURAL AMINO-ACIDS; PROTEIN CROSS-LINKING; ESCHERICHIA-COLI; STRUCTURAL BASIS; EVOLUTION; CODE
- 제목
- Genetic incorporation of L-dihydroxyphenylalanine (DOPA) biosynthesized by a tyrosine phenol-lyase and its applications
- 저자
- Kim, Sang Kil; Lee, Hyun Soo
- 발행일
- 2019-08-25
- 유형
- Meeting Abstract
- 저널명
- ACS National Meeting Book of Abstracts
- 권
- 258
- 호
- 24
- 페이지
- 3002 ~ 3005