Synthesis and characterization of thermoresponsive polymeric nanoparticles

초록

We synthesized drug-loaded thermoresponsive poly(N-isopropylacrylamide) with acrylic acid (poly(NIPAM-co-AA)) nanoparticles. Dynamic light scattering analysis showed that the size of poly (NIPAM-co-AA) nanoparticles was significantly affected by temperatures, indicating that the sizes were changed from 400 nm at 25 degrees C to 100 nm at 37 degrees C. H-1 nuclear magnetic resonance (NMR) and fourier transform infrared spectroscopy (FT-IR) analysis demonstrated the synthesis of poly(NIPAM-co-AA) nanoparticles, showing that drugs (e.g., doxorubicin, retinoic acid) were conjugated with poly(NIPAM-co-AA) nanoparticles. We also analyzed the cumulative release of drugs in a temporal manner, indicating that doxorubicin was highly released from poly(NIPAM-co-AA) nanoparticles at 48 hours compared to retinoic acid. Therefore, this thermoresponsive drug-loaded poly (NIPAM-co-AA) nanoparticle could be a powerful tool for drug delivery and release applications.

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