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SAR Study of β-Aminoacyl-Containing Cyclic Hydrazide Derivatives as DPP-IV Inhibitors
- Jun, Mi Ae;
- Shin, Mi Sik;
- Park, Woul Seong;
- Kang, Seung Kyu;
- Kim, Ki Young;
- ... Lee, Duck Hyung;
- 외 4명
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1초록
In continuation of our efforts to further derivatize dipeptidyl peptidase IV (DPP-IV) inhibitors, a series of beta-aminoacyl-containing 5-, 6- and 7-membered cyclic hydrazide derivatives was synthesized. All the compounds were evaluated for their ability to inhibit DPP-IV, and an optimum structural unit on basic skeleton is identified to show good in vitro activity.
키워드
Dipeptidyl peptidase IV; Diabetes; Cyclic hydrazide; DIPEPTIDYL-PEPTIDASE-IV; GLUCAGON-LIKE PEPTIDE-1; GLUCOSE-TOLERANCE; DISCOVERY; DESIGN
- 제목
- SAR Study of β-Aminoacyl-Containing Cyclic Hydrazide Derivatives as DPP-IV Inhibitors
- 저자
- Jun, Mi Ae; Shin, Mi Sik; Park, Woul Seong; Kang, Seung Kyu; Kim, Ki Young; Rhee, Sang Dal; Lee, Duck Hyung; Cheon, Hyae Gyeong; Ahn, Jin Hee; Kim, Sung Soo
- 발행일
- 2008-11-20
- 유형
- Article
- 권
- 29
- 호
- 11
- 페이지
- 2129 ~ 2134
- 언어
- ENG
- 출판사
- 대한화학회
- 발행국가
- 대한민국
- 분량
- 6 페이지
- ISSN
- E 1229-5949
P 0253-2964