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Asymmetric synthesis of β-amino-α-hydroxy acids through Lewis acid-mediated addition of ketene acetal to imines
- Ha, HJ;
- Ahn, YG;
- Woo, JS;
- Lee, GS;
- Lee, WK
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WEB OF SCIENCE
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18초록
Asymmetric synthesis of fl-amino-a-hydroxy acids, key components of medicinally important molecules including Paclitaxel, KRI-1314, amastatin, and microginin, has been attained from the aldimine coupling of chiral imines N-alkyl-idene-(S)- or (R)-alpha -methylbenzylamine with (Z)-alpha -methoxyketene methyltrimethylsilyl acetal, followed by demethylation, hydrogenolysis, and hydrolysis.
키워드
TAXOL SIDE-CHAIN; (2S,3R)-3-AMINO-2-HYDROXYDECANOIC ACID; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE SYNTHESIS; RENIN INHIBITOR; (3R)-3-AMINODECANOIC ACID; PRACTICAL SYNTHESIS; ESTER UNITS; DERIVATIVES; CYCLOHEXYLNORSTATINE
- 제목
- Asymmetric synthesis of β-amino-α-hydroxy acids through Lewis acid-mediated addition of ketene acetal to imines
- 저자
- Ha, HJ; Ahn, YG; Woo, JS; Lee, GS; Lee, WK
- 발행일
- 2001-09
- 유형
- Article
- 권
- 74
- 호
- 9
- 페이지
- 1667 ~ 1672