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Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation
- Byun, Ji Hun;
- Kim, HyeYun;
- Kim, YoungSoo;
- Mook-Jung, Inhee;
- Kim, Dong Jin;
- ... Lee, Won Koo;
- 외 1명
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67초록
The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for A beta fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for A beta fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC(50) = 0.07 and 0.08 mu M, respectively) than those of Curcumin (IC(50) = 0.80 mu M) and IMSB (IC(50) = 8.00 mu M) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation. (C) 2008 Elsevier Ltd. All rights reserved.
키워드
Alzheimer's disease; A beta 42 fibrils; aminostyrylbenzofurans; inhibitory activity; ALZHEIMERS-DISEASE; AMYLOID PLAQUES; IMAGING AGENTS; PROTEIN; PROBES; BRAIN
- 제목
- Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation
- 저자
- Byun, Ji Hun; Kim, HyeYun; Kim, YoungSoo; Mook-Jung, Inhee; Kim, Dong Jin; Lee, Won Koo; Yoo, Kyung Ho
- 발행일
- 2008-10-15
- 유형
- Article
- 권
- 18
- 호
- 20
- 페이지
- 5591 ~ 5593