Enantioselective total synthesis of (-)-clavosolide B

초록

Enantioselective synthesis of 2, a revised structure for (-)-clavosolide B, was accomplished by a convergent approach, where syn-selective aldol, hydroxy-directed cyclopropanation, Mitsunobu inversion, Schmidt-type glycosylation, and macrolactonization reactions were utilized as key reactions. Comparison of (1)H and (13)C NMR spectra and optical rotation measurement confirmed the relative and absolute stereochemistry of clavosolide B (2).

키워드