A new synthetic route to (3R,4S)-3-hydroxy-4-phenylazetidin-2-one as a taxol side chain precursor

Song, CE; Lee, SW; Roh, EJ; Lee, SG; Lee, WK

doi:10.1016/S0957-4166(98)00049-4

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A new synthetic route to (3R,4S)-3-hydroxy-4-phenylazetidin-2-one as a taxol side chain precursor

Song, CE;
Lee, SW;
Roh, EJ;
Lee, SG;
Lee, WK

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37

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SCOPUS

31

초록

A new synthetic route to (3R,4S)-3-hydroxy-4-phenylazetidin-2-one an important precursor for the paclitaxel side chain, has been developed using intramolecular cyclization of N-(p-methoxyphenyl) (2S,3R)-2-acetoxy-3-bromo-3-phenylpropionamide which can be easily obtained by catalytic asymmetric dihydroxylation of N-(p-methoxyphenyl)-trans-cinnamide, followed by bromoacetylation. (C) 1998 Elsevier Science Ltd. All rights reserved.

키워드

LACTAM SYNTHON METHOD; ALPHA-HYDROXY ACIDS; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC DIHYDROXYLATION; AMINO-ACIDS; BETA-AMINO; HETEROGENEOUS MEDIA; HIGHLY EFFICIENT; TAXOTERE; N-BENZOYL-(2R,3S)-3-PHENYLISOSERINE

제목: A new synthetic route to (3R,4S)-3-hydroxy-4-phenylazetidin-2-one as a taxol side chain precursor

저자: Song, CE; Lee, SW; Roh, EJ; Lee, SG; Lee, WK

DOI: 10.1016/S0957-4166(98)00049-4

발행일: 1998-03-27

유형: Article

저널명: Tetrahedron Asymmetry

권: 9

호: 6

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