An efficient synthesis of morpholin-2-one derivatives using glycolaldehyde dimer by the Ugi multicomponent reaction

  • Kim, YB; 
  • Choi, EH; 
  • Keum, G; 
  • Kang, SB; 
  • Lee, DH; 
  • 외 2명
Citations

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81

초록

[GRAPHICS] A new one-pot procedure for the efficient synthesis of novel 3-substituted morpholin-2-one-5-carboxamide derivatives using commercially available glycolaldehyde dimer as a bifunctional component with various alpha -amino acids and isocyanides by the Ugi five-center three-component reaction (U-5C-3CR) was developed.

키워드

SOLUTION-PHASE SYNTHESIS; ARMSTRONGS CONVERTIBLE ISONITRILE; ALPHA-AMINO-ACIDS; 4-COMPONENT CONDENSATION; LIBRARIES; ISOCYANIDES; PYRROLES; ALCOHOLS; LACTAMS; RESIN
제목
An efficient synthesis of morpholin-2-one derivatives using glycolaldehyde dimer by the Ugi multicomponent reaction
저자
Kim, YB; Choi, EH; Keum, G; Kang, SB; Lee, DH; Koh, HY; Kim, YS
DOI
10.1021/ol016716w
발행일
2001-12-27
유형
Article
저널명
Organic Letters
권
3
호
26
페이지
4149 ~ 4152