Recrystallization of Adefovir Dipivoxil Particles Using the Aerosol Solvent Extraction System Process

초록

In this study, the adefovir dipivoxil particles were recrystallized by using the aerosol solvent extraction system (ASES) process. Supercritical carbon dioxide, which is known to be a green solvent, was adopted as an anti-solvent. The effects of process parameters such as temperature, pressure, solution concentration, and solution injection rate on particle size and its distribution were investigated. To explore the influence of solvents on particle production, ethanol (C2H5OH), methanol (CH3OH), and IPA (isopropyl alcohol, C3H8O) were used as a dissolving solvent for adefovir dipivoxil. As a result, particle size decreased when the system temperature decreased and the system pressure increased. Higher concentration of adefovir dipivoxil in the solution and increasing the solution injection rate also increased particle size. When we use three different kinds of solvents, the order of recrystallized particle size and the width of particle size distribution was methanol < ethanol < IPA. A scanning electron microscope was used to observe the morphology and size of the adefoyir dipivoxil particles recrystallized by the ASES process. The mean particle size and its distribution of processed particles were measured by image analysis software.

키워드