초음파 압력 펄스에 의한 미세기포와 세포 간의 상호작용에 대한 수치적 연구

초록

The collapse of microbubbles using ultrasonic pressure pulses is accompanied by strong shock waves and jets. This phenomenon is an important topic applied to various environmental and medical fields such as surface cleaning, algae removal, cell poration, and drug delivery. However, a numerical model that can capture the strong bubble collapse, liquid jet, and associated deformation of a cell is lacking in the literature. In this work, numerical simulations are performed for the interaction between the spherical bubble and cell under an ultrasonic pulse condition including the effects of bubble collapsing jet and cell deformation. The cell is treated as a compressible liquid and two distance level-set functions are used for the bubble and cell interfaces. The conservation equations of mass and momentum are solved for compressible two-phase flows. The effects of acoustic amplitude and frequency and initial bubble-cell distance are investigated. The results show that cell deformation increases with increasing acoustic amplitude or decreasing frequency, and the distance between the bubble and cell is observed as an important parameter for cell deformation under the same ultrasound conditions. The present work can contribute to a safer and more efficient use of ultrasound in environmental and medical applications.

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