Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates

Ma, Sang-ho; Yoon, Doo Ha; Ha, Hyun-Joon; Lee, Won Koo

doi:10.1016/j.tetlet.2006.11.033

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Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates

Ma, Sang-ho;
Yoon, Doo Ha;
Ha, Hyun-Joon;
Lee, Won Koo

Citations

WEB OF SCIENCE

33

Citations

SCOPUS

35

초록

Enantiopure 1-phenylethylazetidine-2-carboxylates and 2-acylazetidines were prepared and reacted with chloroformates to yield alpha-chloro-gamma-amino butyric acid esters and ketones from ring opening reaction of azetidinium ion intermediate in a completely regio- and stereoselective manner. (c) 2006 Elsevier Ltd. All rights reserved.

키워드

azetidine-2-carboxylate; 2-acylazetidine; chloroformate; ring opening; alpha-chloro-7-amino butyric acid esters; TERTIARY-AMINES; AZETIDINE-2-CARBOXYLIC ACID; N-DEBENZYLATION; 2-ACYLAZIRIDINES; DEALKYLATION; DERIVATIVES; MILD

제목: Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates

저자: Ma, Sang-ho; Yoon, Doo Ha; Ha, Hyun-Joon; Lee, Won Koo

DOI: 10.1016/j.tetlet.2006.11.033

발행일: 2007-01-08

유형: Article

저널명: Tetrahedron Letters

권: 48

호: 2

페이지: 269 ~ 271