인간 결장직장암 세포주들에 미치는 복어 균질액의 성장억제 활성 연구

초록

Cancer is one of the most serious public health problems in Korea and worldwide, and has a major impact on society. Despite significant advances in traditional anti-cancer therapies, such as chemotherapy, radiotherapy, and surgery, it remains extremely difficult to cure and prevent cancer. Consequently, novel anti-cancer therapies must be developed. We previously reported that Globefish homogenate suppresses the growth of Caco-2 human colorectal cancer cells. To build upon this previous observation, we investigated the cytotoxic effects of Globefish homogenate on DLD-1, HCT116, and SW480 human colorectal cancer cells by counting cells and examining morphological changes underneath an inverted microscope. Treatment with Globefish homogenate markedly inhibited the growth of cultured DLD-1, HCT116, and SW 480 cells in a dose-dependent manner. The sensitivities of these cells to Globefish homogenate were determined by calculating the lethal concentrations. The 50% inhibitory concentrations of Globefish homogenate were 111, 95, and 121 mg/mL in DLD-1, HCT116, and SW480 cells, respectively. These results indicate that Globefish homogenate contains a bioactive material(s) that inhibits the growth of human colorectal cancer cells.

키워드