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Preparation of PEG Tethered Ferrocene Modified Polyacrylic Acid/Silica Composite as an Electroactive Polymeric Platform for Biosensors
- Jirimali, Harishchandra Digambar;
- Nagarale, Rajaram Krishna;
- Lee, Jong Myung;
- Saravanakumar, Durai;
- Shin, Woonsup
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10초록
A silica composite of poly(acrylic acid) (PAA) functionalized by ferrocene via polyethylene glycol (PEG) linker (PAA-PEG-Fc/silica) was synthesized and electrochemical properties were characterized. The drop-coated PAA-PEG-Fc/silca composite on screen printed electrode shows a facile reversible redox behavior at E degrees=0.3 V vs. Ag/AgCl at pH 7 in 0.1 M phosphate buffer. The apparent diffusion coefficient in the film was measured to be 2.2 x 10(-7) cm(2)/s. Horseradish peroxidase (HRP) and glucose oxidase (GOx) were successfully immobilized in the composite film and showed a linear response up to 0.5 mM for hydrogen peroxide and 10 mM for glucose.
키워드
Polyethylene glycol; Polyacrylic acid; Ferrocene; Silica composite; Biosensor; GLUCOSE-OXIDASE; AMPEROMETRIC DETERMINATION; REDOX CENTERS; ENZYME; IMMOBILIZATION; ELECTRODE; MEDIATORS; ORMOSIL; SURFACE; DESIGN
- 제목
- Preparation of PEG Tethered Ferrocene Modified Polyacrylic Acid/Silica Composite as an Electroactive Polymeric Platform for Biosensors
- 저자
- Jirimali, Harishchandra Digambar; Nagarale, Rajaram Krishna; Lee, Jong Myung; Saravanakumar, Durai; Shin, Woonsup
- 발행일
- 2011-09
- 유형
- Article
- 저널명
- Electroanalysis
- 권
- 23
- 호
- 9
- 페이지
- 2109 ~ 2115