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Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation
- Byeon, Seong Rim;
- Lee, Ji Hoon;
- Sohn, Ji-Hoon;
- Kim, Dong Chan;
- Shin, Kye Jung;
- ... Lee, Won Koo;
- 외 3명
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New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by A beta fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for A beta fibril formation at IC50 of 0.1-2.7 mu M which is comparable to curcumin (IC50 of 0.8 mu M). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 mu M. In particular, 1-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity. (c) 2006 Elsevier Ltd. All rights reserved.
키워드
A beta fibril formation inhibitor; Alzheimer disease; bis-styrylpyridine; bis-styrylbenzene; amyloid beta; ALZHEIMERS-DISEASE; AMYLOID HYPOTHESIS; ALPHA-SYNUCLEIN; PLAQUES; MEDICINE; CURCUMIN
- 제목
- Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation
- 저자
- Byeon, Seong Rim; Lee, Ji Hoon; Sohn, Ji-Hoon; Kim, Dong Chan; Shin, Kye Jung; Yoo, Kyung Ho; Mook-Jung, Inhee; Lee, Won Koo; Kim, Dong Jin
- 발행일
- 2007-03-01
- 유형
- Article
- 권
- 17
- 호
- 5
- 페이지
- 1466 ~ 1470