An efficient synthesis of both enantiomers of cathinone by regioselective reductive ring opening of substituted aziridines

초록

Both enantiomers of Cathinone were prepared as HCl salts from N-(R)-alpha-methylbenzylaziridine-2(S)-carboxaldehyde 2c and its enantiomer N-(S)-alpha-methylbenzylaziridine-2(R)-carboxaldehyde 3c in high yield. This process makes it possible to prepare other aromatic and heteroaromatic analogs of Cathinone efficiently. Copyright (C) 1996 Elsevier Science Ltd