Synthesis, photophysical properties and photo-induced cytotoxicity of novel tris(diazatriphenylene)ruthenium (II) complex

Samala, Srinivas; Lim, Woojeong; You, Dong Kyun; Lee, Kang Mun; Jo, Hongil; Ok, Kang Min; Park, Jongmin; Lee, Chang-Hee

doi:10.1016/j.bioorg.2022.106044

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Synthesis, photophysical properties and photo-induced cytotoxicity of novel tris(diazatriphenylene)ruthenium (II) complex

Samala, Srinivas;
Lim, Woojeong;
You, Dong Kyun;
Lee, Kang Mun;
Jo, Hongil;
... Ok, Kang Min;
외 2명

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초록

Novel bipyridine-based heterocyclic building block, 3,10-dichloro-benzo[f][1,10]phenanthroline and its Ruthenium(II) complex have been synthesized and fully characterized. The synthesized Ru(II)-complex is highly luminescent displaying emission at 590 nm with quantum yield of ∼0.8 in methanol. Ru(II) complex showed photocytotoxicity upon 400 nm blue light irradiation. Mechanistic study revealed that photoactivated Ru(II) complex generates reactive radical species which can damage the protein inside the cells and induce cell death even with short irradiation time. © 2022 Elsevier Inc.

키워드

Phenanthroline; Photo-induced cytotoxicity; Reactive radical species; Ruthenium complex; π-extension

제목: Synthesis, photophysical properties and photo-induced cytotoxicity of novel tris(diazatriphenylene)ruthenium (II) complex

저자: Samala, Srinivas; Lim, Woojeong; You, Dong Kyun; Lee, Kang Mun; Jo, Hongil; Ok, Kang Min; Park, Jongmin; Lee, Chang-Hee

DOI: 10.1016/j.bioorg.2022.106044

발행일: 2022-11

유형: Article

저널명: Bioorganic Chemistry

권: 128