Enantioselective synthesis of the C14-C25 portion of the cytotoxic natural product, amphidinolide B1

Lee, DH; Rho, MD

doi:10.1016/S0040-4039(00)00208-2

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Enantioselective synthesis of the C14-C25 portion of the cytotoxic natural product, amphidinolide B1

Lee, DH;
Rho, MD

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WEB OF SCIENCE

22

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SCOPUS

23

초록

The C14-C25 portion of the cytotoxic natural product, amphidinolide B1 (1), was synthesized enantioselectively using Myers asymmetric alkylation protocol, epoxide opening with higher order cuprate, Sharpless asymmetric epoxidation of allylic alcohol 17, and Sharpless asymmetric dihydroxylation of 24 as key steps. (C) 2000 Elsevier Science Ltd. All rights reserved.

키워드

TOP HALF; MOIETY; PSEUDOEPHEDRINE; KETONES

제목: Enantioselective synthesis of the C14-C25 portion of the cytotoxic natural product, amphidinolide B1

저자: Lee, DH; Rho, MD

DOI: 10.1016/S0040-4039(00)00208-2

발행일: 2000-04-08

유형: Article

저널명: Tetrahedron Letters

권: 41

호: 15

페이지: 2573 ~ 2576