초음파 방향에 따른 마이크로 버블의 붕괴와 세포 변형에 대한 수치적 연구

초록

Liquid jets and shock waves caused by microbubble collapse are widely used in environmental and medical applications such as algae removal, drug delivery, and cancer cell therapy. However, the relation between bubble collapse and cell deformation in general acoustic conditions is still lacking in the literature. In this work, microbubble oscillation and cell deformation in an acoustic pressure field are numerically investigated using a level-set method for compressible multiphase flows. The cell is modeled as a compressible droplet using gelatin properties which is used as a surrogate for the biomaterial. The bubble and cell interfaces are tracked by the two level-set distance functions, and the mass and momentum conservation equations are solved. The influences of bubble collapse-induced liquid jet and shock wave on cell deformation are compared, and the effects of ultrasound direction and cell size on bubble collapse and cell deformation are investigated.

키워드