In vitro & in vivo studies of intravitreal implantable magnetic micropump for on-demand drug delivery

초록

This paper propose an intravitreal implantable magnetic micropump integrated with micro check valve capable of on-demand vascular endothelial growth factor receptor (VEGFR)-targeted drug delivery for treatment of age-related macular degeneration, diabetic retinopathy and so on. For specifically targeting VEGFR and suppression of VEGF-induced proliferation of microvascular endothelial cells, anti-Flt1 gold nanocomplexes are synthesized. In vitro and in vivo experiments and quantitative analysis are carried out in order to verify our proposed concept: precise drug release control according to external magnetic field, targeting to microvascular endothelial cells, and on-demand and efficient drug delivery from micropump to macular area of rabbit's eye. © © (2018) by Chemical and Biological Microsystems Society. All rights reserved.

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