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Palladium-Catalyzed Divergent Cyclopropanation by Regioselective Solvent-Driven C(sp<SUP>3</SUP>)-H Bond Activation
- Chung, Da Sol;
- Lee, Jae Sung;
- Ryu, Ho;
- Park, Jiyong;
- Kim, Hyunjoong;
- ... Lee, Won Koo;
- 외 4명
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35초록
Reported is a tandem palladium-catalyzed Heck/regioselective C(sp(3))-H activation reaction for the divergent synthesis of spiro- and fused-cyclopropanated indolines from N-methallylated 2-bromoarylamides. The regioselectivity of the C-H bond activation in the s-alkylPdII intermediate is controlled by the solvent used. DFT calculations suggest that the polarity of solvent molecules could influence the transition-state energy, leading to a bifurcation of the C-H bond activation in the s-alkylPdII intermediate.
키워드
C-H activation; heterocylces; palladium; reaction mechanisms; solvent effects; C-H ACTIVATION; FUNCTIONALIZATION; ARYLATION; CONSTRUCTION; RHODIUM; CYCLIZATION; MECHANISM
- 제목
- Palladium-Catalyzed Divergent Cyclopropanation by Regioselective Solvent-Driven C(sp<SUP>3</SUP>)-H Bond Activation
- 저자
- Chung, Da Sol; Lee, Jae Sung; Ryu, Ho; Park, Jiyong; Kim, Hyunjoong; Lee, Joo Hyun; Kim, U. Bin; Lee, Won Koo; Baik, Mu-Hyun; Lee, Sang-gi
- 발행일
- 2018-11-19
- 유형
- Article
- 권
- 57
- 호
- 47
- 페이지
- 15460 ~ 15464